TLCTugger
August 19th, 2007, 11:24
From http://Apligraf.com/how_made
Apligraf, is supplied as living bilayered, cell therapy. It's dermal analog is a collagen matrix populated with fibroblasts which have produced a dermal layer. These dermal elements are obtained from neonatal foreskin. The epidermis is a stratified and multilayer providing a biologic barrier function. The epidermis is also obtained from neonatal foreskin. The foreskin is decontaminated with antibiotics, antifungals, and an ethyl alcohol rinse. Production of cell stocks involves enzymatic digestion of the foreskin tissue and fibroblast/keratinocyte isolation. Apligraf is made by a process that take 20 days. There is a 7 day shipping window. It is individually packaged for use in a nutrient medium and sealed in a polybag. It is shipped overnight via courier. Keep Apligraf in the sealed poly bag, inside the shipping container at 20C-23C; 68F-73F, until use.
Apligraf, is supplied as living bilayered, cell therapy. It's dermal analog is a collagen matrix populated with fibroblasts which have produced a dermal layer. These dermal elements are obtained from neonatal foreskin. The epidermis is a stratified and multilayer providing a biologic barrier function. The epidermis is also obtained from neonatal foreskin. The foreskin is decontaminated with antibiotics, antifungals, and an ethyl alcohol rinse. Production of cell stocks involves enzymatic digestion of the foreskin tissue and fibroblast/keratinocyte isolation. Apligraf is made by a process that take 20 days. There is a 7 day shipping window. It is individually packaged for use in a nutrient medium and sealed in a polybag. It is shipped overnight via courier. Keep Apligraf in the sealed poly bag, inside the shipping container at 20C-23C; 68F-73F, until use.