(getting off topic, but...)
There has been at least one reasonably well designed study of this.
http://www.lancet.com/journals/lance...316-0/abstract
It showed that uncircumcised baby boys have less pain response to vaccinations (done around 4-6 months of age) than do circumcised baby boys; furthermore, using topical anesthetic during circumcision reduced the increased pain response to later vaccinations (but did not eliminate it).
So being circumcised as an infant does lead to a lasting elevation in pain response / negative reactivity (at least on average), and using topical anesthetic during the circumcision procedure probably doesn't eliminate that enduring negative change.
(note that I don't think the uncircumcised group was randomly assigned; only the two circumcised groups)