From Wiki:
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Because usage of tretinoin may cause thinning of the skin, it is strongly recommended that patients who are using the drug abstain from hair removal waxing.[citation needed] The wax will, when removed, pull off the top level of epithelium (skin) with it, leaving a red, inflamed, sore mark for several days.[citation needed] Tweezing or threading (epilation) is a viable option for hair removal. The recommended timeframe to wait for a waxing treatment after using tretinoin varies from source to source; anywhere from five days to three months have been reported. Patients should consult with their aesthetician and dermatologist to discuss the best hair removal options during or after tretinoin use.
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Looks like it causes skin to thin with risk of tearing. Not something I'd be wanting to put on an area of skin where I'll be tugging and applying tension for long hours.
Also, it's meant (obviously) for external use only. You consider your mucosal tissue and glans to be external because you are cut... but they are internal tissues. I wouldn't put this stuff anywhere NEAR my penis.
Also,
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It is a teratogen, and therefore can cause birth defects and tests have shown increases in fetal skull abnormalities in rats. Women who are or may be pregnant, or who are seeking to become pregnant, are therefore warned against using it.[10] This teratogenic effect is caused by the interference of the exogenous retinoic acid with endogenous retinoic acid signaling, which plays a role in patterning the developing embryo. However the risks of topical tretinoin to the fetus seems to be limited.
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Again, if you are sexually active I'm sure a woman doesn't want a penis that was drenched in this anywhere near her vagina.