Excerpt from guidance document:
Sexual transmission accounts for the majority of HIV infections both in the United States and globally. Behavior change through counseling, male and female condoms, antiretroviral therapy for the infected partner, voluntary male medical circumcision, and treatment of STIs can reduce the risk of HIV acquisition. However, despite these prevention methods, HIV incidence in the United States has not declined and remains stable at 56,300 new infections annually (Hall, Song, et al. 2008). Worldwide, the annual incidence is estimated to be about 2.7 million infections (UNAIDS 2011).
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You may want to center comments around the notion that vaginal microbicides are intended to be a "female controlled" anti-HIV measure, but that male circumcision (purportedly) makes it more difficult to insist on condom use or refuse sex, and that some analyses suggest a higher rate of male-female HIV transmission when men are circumcised.
Researching and drafting comments with a view to the relatively straight forwarded matter of having token reference to male circumcision removed from this document would be a good opportunity for readers from the U.S. to start becoming familiar with the formal processes through which regulations are developed (see this post
Please remember that your comments will be read by decision-makers in the FDA and to be firm but respectful (and ideally, provide links to scientific articles and other credible references) if you want to be taken seriously.